Pesquisa sobre: STEROL 14-DEMETHYLASE 
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Descritor Inglês:   Sterol 14-Demethylase 
Descritor Espanhol:   Esterol 14-Desmetilasa 
Descritor Português:   Esterol 14-Desmetilase 
Sinônimos Inglês:   14 alpha-Demethylase, Eburicol
14 alpha-Demethylase, Lanosterol
14-Demethylase, Sterol
14-Demethylases, Sterol
14-alpha-Demethylase, Sterol
14alpha-Demethylase, Eburicol
14alpha-Demethylase, Obtusifoliol
CYP51 Cytochrome P 450
CYP51 Cytochrome P-450
CYP51, Cytochrome P-450
Cytochrome P 450 CYP51
Cytochrome P-450 CYP51
Cytochrome P-450, CYP51
Eburicol 14 alpha Demethylase
Eburicol 14 alpha-Demethylase
Eburicol 14alpha Demethylase
Eburicol 14alpha-Demethylase
Lanosterol 14 alpha Demethylase
Lanosterol 14 alpha-Demethylase
Obtusifoliol 14alpha Demethylase
Obtusifoliol 14alpha-Demethylase
P-450 CYP51, Cytochrome
P-450, CYP51 Cytochrome
Sterol 14 Demethylase
Sterol 14 Demethylases
Sterol 14 alpha Demethylase
Sterol 14-Demethylases
Sterol 14-alpha-Demethylase  
Categoria:   D08.244.453.878.500
D08.244.453.915.880
D08.811.682.690.708.170.499.500
D08.811.682.690.708.170.915.880
D12.776.422.220.453.878.500
D12.776.422.220.453.915.880
Definição Inglês:   An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa. 
Combinados Inglês:   Sterol 14-Demethylase/antagonists & inhibitors use 14-alpha Demethylase Inhibitors
 
Nota Histórica Inglês:   2011 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   54039 
Identificador Único:   D058886 

Ocorrência na BVS: 		 

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